38- year demographic study of central and peripheral giant cell granulomas of the gaws

Objective: the purpose of this study was to retrospectively analyze the demographic characteristics of patients with central peripheral giant cell granulomas [CGCGs] / [PGCGs] an Iranian population

Methods: in this 38-year retrospective study, the data were obtained from records of 1019 patients with CGCG and PGCG of the jaws referred to the Department of Oral and Maxillofacial, Pathology, Mashhad University of Medical Sciences, Iran between 1972 and 2010. Information regarding age distribution, gender, location of the lesion and clinical signs and symptoms was documented

Results: a total of 1019 patients were affected by giant cell granuloma lesions [GCGLs] including 435 CGCGs and 584 PGCGs. The mean age was 28.91 +/- 18.16. PGCGs and CGCGs had a peak of occurrence in the first and second decade of life respectively. A female predominance was shown in CGCG cases [57.70%], whereas PGCGs were more frequent in males [50.85%]. Five hundred and ninety eight cases of all giant cell lesions [58.7 %] occurred in the mandible. Posterior mandible was the most frequent site for both Lesions. The second most common site for PGCG was posterior maxilla [21%], whereas anterior mandible was involved in CGCG [19.45%]. The majority of patients were asymptomatic. Patient's age, location [mandible/maxilla] and bleeding were the influential variables on the type of the lesion

Conclusion: although the CGCGs share some histopathologic similarities with PGCGs, differences in demographic features may be observed in different populations

immunohistochemical survey to evaluate the expression of cd105 and cd34 in ameloblastoma and odontogenic keratocyst

Statement of the Problem: Ameloblastoma is the most common odontogenic tumor which is slow-growing, locally invasive and exhibit specific biologic behavior and high recurrence rate. Likewise, odontogenic keratocyst is a developmental odontogenic cyst that has a high recurrence rate and aggressive behavior. There are limited studies considering the relationship between the angiogenesis factors and the biologic behavior of these lesions

Purpose: the aim of this study was to evaluate the mean density of vessels in odontogenic keratocysts and ameloblastoma and investigate its possible relationship with biological behavior of these lesions

Materials and Method: In this descriptive-analytic cross-sectional study, 40 cases, comprising 10 odontogenic keratocysts and 30 ameloblastomas [10 plexiform, 10 follicular, and 10 unicystic type] were selected and were stained immuno-histochemically with CD34 and CD105. The micro vessel density was assessed and compared in all groups. T- test for the independent samples' One- way Anova, Wilcoxon test and Tukey tests were adopted for statistical analysis

Results: A statistically significant difference was observed in mean vascular density [MVD] between the odontogenic keratocyst and ameloblastoma groups concerning the CD105 and CD34 markers [p= 0.005, p= 0.000, respectively]. The MVD was significantly higher in ameloblastomas than odontogenic keratocyst. MVD with CD34 was significantly higher than MVD with CD105 in ameloblastomas [p= 0.00]

Conclusion: It can be suggested that angiogenesis might be one of the mechanisms that is more possible to contribute the aggressive biological behaviors in ameloblastoma rather than odontogenic keratocyst

Glandular odontogenic cyst of the posterior maxilla

The glandular odontogenic cyst is an uncommon developmental odontogenic cyst described as a distinct entity by Gardner et al. in 1988. The Glandular odontogenic cyst occurs more commonly in middle-aged people and has a predilection for the mandible. Only histopathological examinations allow for certain diagnosis of the cyst. The increased recurrence rate can be due to its multilocularity and incomplete removal of the lining following conservative treatment. This article presents a case of glandular odontogenic cyst in a 28-year-old male patient in the posterior region of the maxilla, which is quite rare

Gorlin-Goltz syndrome

We report a case of Gorlin-Goltz syndrome in a 21-year-old man. Gorlin-Goltz syndrome [basal cell nevus syndrome] is an infrequent hereditary disease with its prevalence varying from 1 / 57,000 to 1/250,000. It is principally characterized by a wide range of developmental abnormalities. Main clinical manifestations include multiple odontogenic keratocysts of the jaws, facial basal cell carcinomas and skeletal anomalies. The prevalence varies from 1/57,000 to 1/250,000